Cutaneous manifestations are seen in disseminated disease. Cryptococcus neoformans is a rare cause of meningitis in immunocompetent children. India ink staining shows the organisms directly with an approximate sensitivity of 70%, whereas CSF cryptococcal latex antigen testing has a sensitivity approaching 90%. Opening pressures may be quite elevated on LP, and CSF values usually reveal a normal CSF glucose concentration, a mildly elevated CSF protein concentration, and a CSF leukocyte count of less than 20/mL. Diagnosis is usually made on examination of cerebrospinal fluid (CSF). Seizures or focal neurologic presentations are rare, and neck stiffness and/or photophobia are usually absent. India ink staining of CSF demonstrates encapsulated yeasts in 60 to 80 of cases, but many laboratories in the United States no longer perform this test. Symptoms may be present for several weeks, and diagnostic delay is common. Cryptococcus may be identified occasionally on a routine Gram stain preparation of CSF as poorly staining Gram-positive yeasts. This case study suggests that primary cutaneous cryptococcosis can be diagnosed provisionally by a simple Gram stained smear and India ink examination in order. The onset tends to be insidious with fairly nonspecific symptoms such as fever, nausea, and headache. Cryptococcal meningoencephalitis typically manifests itself in patients whose CD4 cell counts are less than 50/mm 3. ) This image is a light micrograph of India inkstained C. Cryptococcus neoformans is the most common cause of meningitis in patients with HIV/AIDS. India Ink Stain ( Cryptococcus neoformans) India Ink Stain (.
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